BRAIN TUMOR INFORMATICS
IN SILICO SCIENCE
CLINICAL AND TRANSLATIONAL INFORMATICS
HIGH END COMPUTING
IMAGING INFORMATICS

Systems Biology

Share Last Updated: June 28, 2012


Investigations into Systems Biology of Diffuse Gliomas


Larger scale histological structures, such as necrosis and hypoxia-driven blood vessel growth (angiogenesis or microvascular hyperplasia), are linked with tumor development through increasingly well-characterized molecular mechanisms. Investigations of necrosis in TCGA frozen sections have revealed links between necrosis and recognized transcriptional classes of glioblastoma. Investigations of the correlations between transcription and necrosis in TCGA have illustrated that hypoxia induces key transcriptional factors that regulate these transcriptional classes, suggesting that the observable microenvironment is a critical factor in establishing tumor subclass.

Reference

  1. Lee A. D. Cooper, David A. Gutman, Qi Long, Brent A. Johnson, Sharath R. Cholleti, Tahsin Kurc, Joel H. Saltz, Daniel J. Brat, Carlos S. Moreno, "The proneural molecular signature is enriched in oligodendrogliomas and predicts improved survival among diffuse gliomas." PloS one 5(9): e12548, September 2010.

HOME | CONTACTS | EMERGENCY | EMPLOYMENT | MAKE A GIFT | EMORY'S WEB | SITE MAP | A-Z INDEX

Copyright © 2017 Emory University - All Rights Reserved | 201 Dowman Drive, Atlanta, Georgia 30322 USA 404.727.6123