BRAIN TUMOR INFORMATICS
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Neuroradiology

Share Last Updated: June 28, 2012


Neuro-imaging Predictors of Molecular Profile and Outcome for Glioblastoma

We have carried out studies investigating the utility of imaging-based biomarkers in predicting overall survival, pathology features and molecular signatures. In collaboration with an NCI led consortium, we have analyzed pre-surgical MRI images of GBM patients whose tissues had been molecularly analyzed in the Cancer Genome Atlas study. We jointly carried out a qualitative assessment of imaging based tumor characteristics such as necrosis and contrast enhancement and found that these characteristics significantly predict overall survival. We have also found that molecularly defined tumor subtypes show observable differences in macroscopic appearance.

References

  1. Scott N Hwang, Chad A Holder, Erich Huang, Bob Clifford, Dima Hammoud, Prashant Raghavan, Manal Jilwan, Max Wintermark, David A Gutman, Lee Cooper, Carlos Moreno, Justin Kirby, John Freymann, Seena Dehkharghani, Arun Krishnan, Carl Jaffe, Adam Flanders, Joel H Saltz, “Associations Between MR Imaging and Genomic Features of Glioblastomas”, American Society of Neuroradiology (ASNR) 49th Annual Meeting & the Foundation of the ASNR Symposium 2011, June 2011.

     
  2. Scott N Hwang, Bob Clifford, Erich Huang, Dima Hammoud, Manal Jilwan, Prashant Raghavan, Max Wintermark, David A Gutman, Carlos Moreno, Lee Cooper, John Freymann, Justin Kirby, Arun Krishnan, Seena Dehkharghani, Carl Jaffe, Joel H Saltz, Adam Flanders, Daniel J Brat, Chad A Holder, “Relationship between MR Imaging Features, Gene Expression Subtype, and Histopathologic Features of Glioblastomas”, American Society of Neuroradiology (ASNR) 49th Annual Meeting & the Foundation of the ASNR Symposium 2011, June 2011.

     
  3. David A Gutman, Lee AD Cooper, Doris Gao, Max Wintermark, Lisa Scarpace, Erich Huang, Manal Jilwan, Tom Mikkelsen, Rajan Jain, Scott N Hwang, Robert J Clifford, Prashant Raghavan, Chad A Holder, Dima Hammoud, Pat Mongkolwat, John Freymann, Carlos Moreno, Justin Kirby, Arun Krishnan, Carl Jaffe, Seena Dehkharghani, Rivka Colom, Joel Saltz, Adam Flanders, Dan Brat, “Neuroimaging predictors of survival, pathology and molecular profiles in TCGA glioblastomas”, The Cancer Genome Atlas' 1st Annual Scientific Symposium: Enabling Cancer Research Through TCGA, November 2011.

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