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Carlos Moreno, PhD

Share Last Updated: December 08, 2011


Associate Professor, Pathology and Laboratory Medicine
Associate Professor, Biomedical Informatics

Research Summary: Focus - Cancer bioinformatics and DNA microarray analysis of tumors; systems biology research of prostate, breast, and brain tumors to identify new drug targets and biomarkers. Dr. Moreno's main research interests are in translational cancer bioinformatics and systems biology, to identify diagnostic markers for more effective and personalized therapies, to identify new potential therapeutic targets, and to better understand the biology of tumor progression. His research has focused on the dissection of the perturbed transcriptional networks in prostate, brain, breast, and ovarian cancers using DNA microarrays. His lab has identified several genes that are strongly correlated with prostate cancer progression, including two developmental transcription factors, HOXC6 and SOX4. The lab is also developing mRNA and microRNA biomarkers of recurrence in prostate cancer. Dr. Moreno's lab analyzes genome-wide expression profiles, transcriptional networks, ChIP-chip studies, biological pathways, and evolutionarily conserved transcription factor binding sites to dissect cancer-related transcriptional networks and identify new drug targets and biomarkers.

Dr. Moreno specialized in cancer bioinformatics and systems biology, analysis of genome-wide expression profiles, transcriptional networks, ChIP-chip studies, biological pathway analysis, and computational analysis of transcription factor binding sites.  At the Emory Center for Comprehensive Informatics he is the Lead Investigator for Bioinformatics Analysis of Genomic and Molecular Datasets at the In Silico Brain Tumor Research Center (ISBTRC).  At the ISBTRC they are performing integrative genomic and image data analysis of glioblastomas using public data derived from The Cancer Genome Atlas (TCGA) project.  His main research interests are in translational cancer bioinformatics, to identify diagnostic markers for more effective and refined therapies, to identify new potential therapeutic targets, and to better understand the biology of tumor progression.  Dr. Moreno's lab has identified several genes that are strongly correlated with prostate cancer progression.  They have published important findings on two developmental transcription factors, HOXC6 and SOX4, whose expression are strongly correlated with cancer progression. In addition to this work, he is also developing biomarkers of recurrence in prostate cancer. Based on genome-wide analyses of SOX4 and HOXC6, their data suggest that, these two factors may represent a link between Wnt and Notch signaling during normal development and during cancer progression.  The transcriptional networks regulated by SOX4 and HOXC6 suggest crucial roles for these factors in proliferation, survival, and metastasis of prostate cancer cells.  Increased expression of these developmental transcription factors may enhance activation of signal transduction pathways such as Notch and PI3K-AKT, contributing to prostate cancer progression and metastasis.  In addition, SOX4 appears to regulate Dicer, Argonaute 1, and DHX9, suggesting a crucial role in regulation of microRNA processing.

Publications

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